Single-dose FTY720 pharmacokinetics, food effect, and pharmacological responses in healthy subjects
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چکیده
منابع مشابه
A Randomized, Open, Single-Centre, Crossed Study of the Effect of Food on the Pharmacokinetics of One Oral Dose of Alflutinib Mesylate Tablets (AST2818) in Healthy Male Subjects
The aim of the study was to study the PK of AST2818 tablets after one oral dose in healthymale subjects on an empty stomach and in a postprandial state and to evaluate the effect of food onAST2818 bioavailability. Sixteen healthy Chinese male subjects were randomly divided into twogroups: a fasting-postprandial group and a postprandial-fasting group. T...
متن کاملA Randomized, Open, Single-Centre, Crossed Study of the Effect of Food on the Pharmacokinetics of One Oral Dose of Alflutinib Mesylate Tablets (AST2818) in Healthy Male Subjects
The aim of the study was to study the PK of AST2818 tablets after one oral dose in healthymale subjects on an empty stomach and in a postprandial state and to evaluate the effect of food onAST2818 bioavailability. Sixteen healthy Chinese male subjects were randomly divided into twogroups: a fasting-postprandial group and a postprandial-fasting group. T...
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AIMS To evaluate apixaban single dose safety, tolerability, pharmacokinetics and pharmacodynamics and assess the effect of food on apixaban pharmacokinetics. METHODS A double-blind, placebo-controlled, single ascending-dose, first-in-human study assessed apixaban safety, pharmacokinetics and pharmacodynamics in healthy subjects randomized to oral apixaban (n = 43; 0.5-2.5 mg as solution or 5-...
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Drug-drug interactions between antiretroviral medications and rifampin complicate the treatment of HIV and tuberculosis coinfection. This study evaluated the effect of rifampin on the pharmacokinetics of oral cabotegravir, an integrase strand transfer inhibitor being investigated for long-acting treatment and prevention of HIV-1 infection. This was a phase I, single-center, open-label, fixed-se...
متن کاملSingle-dose pharmacokinetics of indinavir and the effect of food.
Indinavir sulfate is a human immunodeficiency virus type 1 (HIV-1) protease inhibitor indicated for treatment of HIV infection and AIDS in adults. The purpose of this report is to summarize single-dose studies which characterized the pharmacokinetics of the drug and the effect of food in healthy volunteers. Indinavir concentrations in plasma and urine were obtained by high-pressure liquid chrom...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2004
ISSN: 0306-5251,1365-2125
DOI: 10.1111/j.1365-2125.2003.02065.x